First Strike explores the early days of Overwatch, the elite international strike team that was assembled to save humanity. Players learn more about the origins of some of its founding members like Jack Morrison, Gabriel Reyes, Ana Amari, Torbjörn Lindholm, and Reinhardt Wilhelm, years before the events of the game, when the Omnic Crisis started.
The comic was planned to be released in November 2016 for the digital edition, and April 2017 for the physical hard cover edition. On 18 November, 2016, the lead writer, Michael Chu, released a statement on the Overwatch forums about the cancellation of the comic. The reason for the cancellation was because "[the team] decided to take [Overwatch's] story in a different direction". He also stated that they still plan to tell this story in another form.